Serious safety concerns are rare but include: Systemic infections : Immunocompromised individuals, those with central venous catheters, or patients with damaged gut barriers face increased risk of bacteremia or fungemia from probiotic organisms [19] [20] Antibiotic resistance transfer : Some probiotic strains may carry antibiotic resistance genes Metabolic complications : Rare cases of D-lactic acidosis have been reported with high-dose probiotic use [25] Specific populations requiring caution include patients with severe acute pancreatitis (based on the PROPATRIA trial showing increased mortality), short bowel syndrome, immunosuppression (HIV/AIDS, chemotherapy, organ transplant recipients), and critically ill individuals
When oxidative throughput approaches or exceeds regenerative redox-buffering capacity under constrained substrate inflow, a rate-limiting metabolic state can be conceptualizedreferred to here as a redox bottleneck as discussed in Sect
This work was supported by grants from the Department of Defense (W81XWH-19-1-0410, W81XWH-22-1-0686 and HT9425-23-1-0424 (D.E.F.)), the National Institutes of Health (R01CA184208 (D.E.F.)), an UT MD Anderson Cancer Center Quantitative Imaging Analysis Core (QIAC) Pilot Grant (D.E.F.), and a grant from the Mike Slive Foundation for Prostate Cancer Research (D.E.F.)
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